With the most recent triumph of developing the world’s first completely synthetic eukaryotic chromosome under the leadership of Dr. Jef Boeke’s Johns Hopkins lab it is clear that ambitions within the field of Synthetic Biology are growing larger every day. With these incredible undertakings come larger sequences, and with these larger sequences come larger teams manipulating larger selections of DNA. With a team as large as the 80 published collaborators who worked on Dr. Boeke’s yeast chromosome it is imperative that all individuals communicate and stay in sync with project progress to ensure an endeavor doesn't collapse into chaos under its own weight. Without a doubt the very near future will have even bigger teams working on enormous genetic codes.
One must ask “how can the details of modification and project communication be achieved with so many people involved?” Genome Compiler has the answer; within the project itself.
Real-time information is the key to developing a working model of efficiency for scientists editing a single genome encompassing not only diverse members of a design team in a single laboratory but for individuals anywhere in the world. With thorough descriptions of changes or notes describing creative solutions throughout the project interface itself communication is standardized to such a level that there is constant dialogue throughout even the most minute details of a Synbio undertaking. By harnessing this idea one can picture a future where the thought process of a single scientist can be traced through a sequence by a thousand others the world over, with two thousand eyes discovering the way over obstacles once deemed insurmountable.
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Loading the new SYNIII Yeast chromosome in Genome Compiler is easy; Enter the NCBI accession code KJ463385 in the NCBI search box and get started modifying today.
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With the addition of Track Changes, edits implemented by individual members of a design team on a single project are now shown in real-time throughout a sequence. Throughout all abstraction views indicator flags will appear over modified portions of the sequence. Upon a mouse over, these flags will show the user responsible for a change, the time of the edit as well as details describing the change itself. Changes made in more focused zooms such as DNA View will be shown in the broader zooms such as Parts View where clicking on a flag will bring the user to the zoom where the edit was made and highlight the change. A concise summary table is also available where all the tracked changes and their details are shown together.
Similarly the User Comments feature allows for clearly organized communication between collaborators in real time within a project itself. User created comments highlighting specific selections are shown to all design team members within a project as indicator flags and can be selected within more shallow views to zoom to intricate details. A summary table highlighting all comments and their specificities is also accessible to allow for an easily digestible overview.
Be sure to learn the particulars of the new User Comments and Track Changes features through our helpful tutorial videos here.